Proponents of H.4050 told the Joint Committee on Revenue that a regulated, permit‑based system for psilocybin would reduce harm and create safer access for patients who already use the substance outside medical settings.

Graham Moore of Mass Healing said the bill "does not have any decriminalization" and would provide screened, regulated access. Jamie Morey and other Mass Healing witnesses described personal and clinical experiences and urged a legal, monitored option for people seeking therapeutic benefit outside strictly medical models.

Joseph McKay, a retired New York City firefighter, described years of treatment‑resistant cluster headaches and post‑9/11 PTSD and credited psilocybin with remission and mental‑health improvements. "Psilocybin healed me both physically and mentally," he testified, describing personal use and citing observational studies and patient advocacy groups that have documented benefits for cluster headache.

Supporters argued the bill would create permit and safety requirements — health screenings, mandatory safety education, and trained facilitators — to reduce risks associated with underground markets. Opponents were not represented in the hearing for this item; committee members asked questions about medical oversight, equity, and how H.4050 would relate to proposed pilot therapeutic programs in other bills.

Witnesses emphasized that regulated access could redirect funds from the underground market into tax revenue for equity and community health programs and said psilocybin has a low toxicity profile compared with many prescription drugs. No committee action was taken at the hearing; witnesses were invited to submit written testimony and technical materials to committee staff.